Skin Autofluorescence Is Not Increased in Patients with Systemic Sclerosis PDF Print E-mail
Thursday, 01 March 2012 15:52
M. E. Hettema, H. Bootsma, R. Graaff, R. de Vries, C. G. M. Kallenberg, and A. J. Smit
Received 24 May 2011; Accepted 8 August 2011

Vascular involvement is a key factor in major manifestations of systemic sclerosis (SSc), such as Raynaud’s phenomenon (RP), myocardial dysfunction, pulmonary hypertension, and renal involvement. Microvascular involvement, in which endothelial injury is present, is the main characteristic of SSc. Oxidative stress has been suggested as a major player in the process of endothelial dysfunction found in SSc. Endothelial damage may be induced by oxygen free radicals and reactive nitrogen species, generated locally by the inflammatory process and by periods of tissue ischemia followed by postischaemic reperfusion. This socalled ischaemic-reperfusion injury can be seen in RP. Increased levels of antibodies against oxidised low-density lipoproteins (LDL) and increased serum levels of 8-isoprostane, being markers of oxidative stress, have, indeed, been observed in SSc.

Oxidative or carbonyl stress, leading to formation of so-called reactive carbonyl compounds, is an important source for the generation of so-called advanced glycation endproducts (AGEs). AGE generation as a result of oxidative stress has also been found in inflammatory diseases, such as rheumatoid arthritis and SLE.

Tissue autofluorescence (AF) is a marker of the accumulation of AGEs, validated in different patient groups and healthy controls. Therefore, we assessed AGE accumulation in patients with SSc and hypothesized that AGE accumulation is increased in patients with SSc compared to healthy controls based on the presence of oxidative stress and endothelial dysfunction in SSc. We related AGE accumulation to the presence of disease-related and traditional cardiovascular risk factors.

Continue reading the full article, by downloading it from the link provided below.

More articles :

» Basal Activation of Type I Interferons (Alpha2 and Beta) and 2'5'OAS Genes

Danilo Bretas de Oliveira, Gabriel Magno de Freitas Almeida, Antonio Carlos Martins Guedes, Flavia Patrıcia Sena Teixeira Santos, Claudio Antonio Bonjardim, Paulo Cesar Peregrino Ferreira, and Erna Geessien KroonReceived 15 June 2011; Revised 10...

» Real-World Bosentan Therapy Successful in Pulmonary Arterial Hypertension: Presented at ATS

Real-life experiences in treating patients with pulmonary arterial hypertension with bosentan appears to provide similar efficacy as seen in clinical trials -- despite patients being somewhat older and having more scleroderma, researchers said today...

» Novel Pharmaceutical Treatment for Scleroderma Discovered

A novel pharmaceutical treatment for scleroderma, comprising the administration of miR-29, has been discovered by Steffen Gay, Oliver Distler and Britta Maurer of the Department of Rheumatology at Zurich University. Scleroderma is a chronic...

» Sonographic Evaluation of Pediatric Localized Scleroderma Preliminary Disease Assessment Measures

Background: Our earlier work in the ultrasonograpy of localized scleroderma (LS) suggests that altered levels of echogenicity and vascularity can be associated with disease activity. Utrasound is clinically benign and readily available, but can be...

» The Secrets of An Ancient Chinese Remedy, Revealed

For roughly two thousand years, Chinese herbalists have treated malaria using a root extract, commonly known as Chang Shan, from a type of that grows in Tibet and Nepal. Recent studies suggest that , a compound derived from the extract’s bioactive...

» Autoimmune Disease Symptoms To Look Out For

We have understood for  a long time that the detection and subsequent diagnoses of autoimmune diseases are difficult. However, there are key rheumatic and physical indicators such as joint pain and fatigue, fevers, increasing skin conditions,...