Scleroderma Drug In Development PDF Print E-mail
Friday, 16 October 2009 10:57
According to The Commercial Appeal, arGentis Pharmaceutical has partnered with Shattuck Hammond Partners, the health care investment arm of Morgan Keegan and Co. Inc., to jump-start a capital campaign to raise $12 million to $15 million. ArGentis shelved the campaign last year when the economy soured.

The money will help continue a three-year effort by arGentis to shepherd a treatment for Scleroderma, an autoimmune disease that affects blood vessels and connective tissue. Ted Townsend, the company's vice president of business development, said the treatment could be on the market as early as 2013.

The company has just finished reviewing the treatment's previous clinical trial. The next trial will be the drug's last before it heads to the Food and Drug Administration for market approval. To help that process along, arGentis has assembled a "dream team" to serve on its scientific advisory board.

For example, new board member Maureen D. Mayes wrote "The Scleroderma Book" in 1999. University of California Los Angeles professor Daniel Furst, Georgetown School of Medicine professor Virginia D. Steen and UCLA biostatistics professor Weng Kee Wong also joined the arGentis scientific advisory board.

"These physicians understand this disease process better than anyone in the world," said Townsend. "Their participation in the trial shows the validity of our therapy and will hopefully reinforce our credibility to regulatory authorities."

However, Charles Spaulding, vice president of communications with the Scleroderma Research Foundation, said the disease largely flies under national research radar.

"There's not enough researchers looking at the disease and not enough money being spent on Scleroderma research," Spaulding said.

ArGentis' Scleroderma treatment received "orphan status" in the United States and in the European Union. The designation gives the company market exclusivity for seven years here and 10 years in Europe.

Townsend said the treatment could be a $1 billion annual opportunity in the U.S. and Europe.

The company also has license agreements in hand for about 50 markets globally.

To view the full article, click here.
 
More articles :

» PDE-5 Inhibitors in Scleroderma Raynaud Phenomenon and Digital Ulcers

Systemic sclerosis- (SSc-) related vasculopathy, as manifested by Raynaud’s Phenomenon (RP) and digital ulcers (DUs), is associated with significant impairment of the quality of life and morbidity. The current vasoactive approach for SSc-RP,...

» Targeting Systemic Sclerosis: From Bioinformatics to Clinical Research

Systemic sclerosis (SSc), also known as Scleroderma, is a rare autoimmune connective tissue disorder that's difficult to treat. However, thanks to new research at Dartmouth's Geisel School of Medicine and Northwestern University's Feinberg School of...

» What's Your Scleroderma Action Plan?

Living with any serious disease or condition like Scleroderma, is without a doubt, difficult. It is not hard to understand either, that we often can lose sight of what is important, including our way. We may also fall into to a false sense of...

» B-Cell Depletion Therapy in Systemic Sclerosis: Experimental Rationale and Update on Clinical Evidence

Dimitrios Daoussis, Stamatis-Nick C. Liossis, Georgios Yiannopoulos, and Andrew P. AndonopoulosDivision of Rheumatology, Department of Internal Medicine, Patras University Hospital, University of Patras Medical School, Rion, 26504 Patras,...

» Predictors Of Interstitial Lung Disease In Early Systemic Sclerosis

Introduction: The objective of the present study was to examine the association of baseline demographic andclinical characteristics with sequentially obtained measurements of forced vital capacity (FVC), expressed as apercentage of the predicted...

» Primary Biliary Cirrhosis Associated with Systemic Sclerosis: Diagnostic and Clinical Challenges

Cristina Rigamonti, Dimitrios P. Bogdanos, Maria G.Mytilinaiou, Daniel S. Smyk, Eirini I. Rigopoulou, and Andrew K. BurroughsReceived 3 June 2011; Accepted 7 September 2011Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease...