Simple Predictor In Scleroderma Related Interstitial Lung Disease PDF Print E-mail
Tuesday, 23 October 2012 23:18
Patients at high risk of deterioration or death from Systemic Sclerosis-related interstitial lung disease can be readily spotted using CT scans, suggest Melbourne researchers.

Patients classified as having “extensive” (> 20%) lung disease as seen on an HRCT-lung  scan were three times more likely to die, need supplementary oxygen or a lung transplant, the authors wrote in Rheumatology.

Baseline HRCT-lung scans were available for 172 patients, who were followed for a mean of 3.5 years, with 30 experiencing an adverse outcome.

The level of lung disease identified on the scans was graded as ‘extensive’ (>20%), ‘limited’ (<20%) or ‘indeterminate’. Those classified as ‘indeterminate’ were allocated to either extensive or limited by looking at forced vital capacity, the authors said.

“I think it’s very important to have a HRCT-lung [scan] to confirm the diagnosis of interstitial lung disease in patients with Scleroderma,” author Dr Mandana Nikpour of the University of Melbourne and St Vincent’s Hospital Melbourne told Rheumatology Update.

“What we have confirmed is that there is an added value in that enables one to prognosticate as well.”

However Dr Nikpour did not recommend serial HRCT-lung scans because of the radiation exposure and cost and said that performing serial pulmonary function tests was a better way to track changes over time.

Saying that their grading system was “simple and quick” the authors proposed “the routine use of this HRCT grading system to obtain prognostic information in patients with SSc-ILD.”

Source: Pain, C (2012), "Simple predictor in systemic sclerosis-related ILD"; Rheumatology Update; Original article can be viewed here.

 
More articles :

» Unite Against Scleroderma

{gallery}unite{/gallery}

» New Biomarker Predicts Poor Outcomes in Scleroderma

A novel biomarker may aid in establishing the prognosis of Systemic Sclerosis (Scleroderma), and particularly in predicting the most common lethal complications, an international group of researchers reported.Patients with Systemic Sclerosis who had...

» March Designated as 'National Autoimmune Diseases Awareness Month' in the U.S.

On the evening of March 4, 2010, the U.S. Senate passed a resolution designating March as "National Autoimmune Diseases Awareness Month" and supporting efforts to increase awareness of autoimmune diseases and increase funding for autoimmune disease...

» Godrick Weekes

I am thirty seven years old and I have for the past four years. For me, it has been a roller coaster ride with this condition and its symptoms. In the beginning, I first noticed that my fingers were always swollen on mornings, I could not bend them...

» Study Reveals New Genetic Link To Scleroderma

An international research consortium including scientists from T (UTHealth) has identified a new genetic link to the systemic form of . Researchers believe a thorough understanding of the genetic nature of the disease is crucial to developing a...

» The World's First Successful Stem Cell Treatment of Autoimmune Diseases

The efficacy on intravenous infusion of adipose-derived mesenchymal stem cells was studied by researchers from five different countries—South Korea, United States, Japan, China, and Germany. These findings were reported in the Journal of...