When Our Antibodies Turn On Us PDF Print E-mail
Friday, 02 March 2012 11:56
More than 32 million Americans harbor potentially toxic proteins that can attack body tissues and lead to autoimmune diseases such as Lupus and Scleroderma, according to a new University of Florida study. This is the first accurate estimate of the frequency of the proteins, called autoantibodies, the researchers say. The findings appear online and in an upcoming print edition of the journal Arthritis and Rheumatism.

“This study is a baseline that can help physicians understand, when they identify autoantibodies, how often these proteins indicate disease,” said lead author Edward Chan, a professor of oral biology in the UF College of Dentistry.

The body produces proteins called antibodies to fight against infections, but in some cases, these proteins become turncoats, attacking the body’s own tissues instead. The most common autoantibodies, called antinuclear antibodies, are frequently used as a marker for autoimmune diseases. Although antinuclear antibodies are common, their presence does not always indicate disease.

Chan, and co-lead author Dr. Minoru Satoh, an associate professor of rheumatology and clinical immunology in the UF College of Medicine, along with national colleagues, studied five years’ worth of data from almost 5,000 people, collected through the National Health and Nutritional Examination Survey. The survey amasses a host of health information from adults and children around the country using questionnaires, blood tests and other medical examinations. No previous researchers have used such a large sample, representative of the general population, to study how frequently autoantibodies occur, Chan said.

The researchers looked for the rogue antibodies in blood serum using an advanced microscope technique that uses a fluorescent dye to selectively light up antinuclear antibodies.

They found that nearly 14 percent of the study population had antinuclear antibodies. The antibodies were more common in African-Americans, women and older adults. The frequency of antinuclear antibodies tends to increase with age then level off over time. And women were more likely to develop antinuclear antibodies as they age.

Unexpectedly, autoantibodies were less common in overweight and obese individuals than in people of normal weight.

“Being obese is often considered a factor contributing to many autoimmune diseases,” Chan said. “So we expected that overweight people might have more autoantibodies. But that is not what we observed.”

Judy Van De Water, a professor of rheumatology and clinical immunology at the University of California, Davis, who was not part of the study, was intrigued that autoantibodies were less common in overweight individuals. She chalks it up to the appetite-reducing hormone leptin — which is produced in fatty tissue and acts as a marker of inflammation. Leptin is often low in people who are obese but high in people who have antibodies that attack the body’s own tissues.

Future studies might look at how exposure to chemicals and other substances in the environment affects the levels of antinuclear antibodies in the immune system, as well as how those levels change over time.

“This is an important study that will serve as the basis for future research on the causes of these antibodies and related diseases,” said the study’s senior author Dr. Fred Miller, acting clinical director of the National Institute of Environmental Health Services, which funded the study. “It’s a first step in the process.”

Radman, M. (2012), "Traitor proteins that could attack the body widespread, UF researchers find", University of Florida News;
 
More articles :

» Pulmonary Hypertension In Systemic Sclerosis

A.J. MacGregor, R. Canavan, C. Knight, C.P. Denton, J. Davar, J. Coghlan, and C.M. BlackPublished: 2001

» BNP Screening for PAH in Scleroderma

An elevated level of N-terminal pro-brain natriuretic peptide (NT-proBNP) has a high sensitivity and specificity for pulmonary arterial hypertension in patients with systemic sclerosis (SSc-PAH), Australian rheumatologists and cardiologists have...

» Pressure and Pain In Systemic Sclerosis/ Scleroderma

Begonya Alcacer-Pitarch, Maya H Buch, Janine Gray, Christopher P Denton, Ariane Herrick, Nuria Navarro-Coy, Howard Collier, Lorraine Loughrey, Sue Pavitt, Heidi J Siddle, Jonathan Wright, Philip S Helliwell, Paul Emery, Anthony C RedmondStudy...

» New Formulation of PAH Medication Is Now Available

Epoprostenol for Injection, an improved formulation of epoprostenol that is stable at room temperature, is now commercially available, according to the drug's maker, Actelion Pharmaceuticals US, Inc., of South San Francisco, Calif.The product is...

» Women At Higher Risk For Autoimmune Diseases

In a recent article on , it was reiterated that women are at a significantly higher risk of contracting an autoimmune disease than men, according to an expert in the field. Dr Vivian Pinn, director of the National Institutes of Health recently...

» Rituximab for Scleroderma: Does Something Finally Work?

Kevin Deane, MDPosted: 03/10/2010Experience With Rituximab in Scleroderma: Results From a 1-Year, Proof-of-Principle StudyDaoussis D, Liossis SN, Tsamandas AC, et al. Rheumatology (Oxford). 2010;49:271-280BackgroundMultiple drugs have been tried in...

Comments  

 
+1 #1 Debi Parrish 2012-03-27 19:38
Thank you from a mom who lost two daughters to an autoimmune diseases, Primary Pulmonary Hypertension and Diffused Systemic Scleroderma. I knew there must be some connection.
Report to administrator