Vitamin D Deficiency May Hasten Autoimmune Lung Disease PDF Print E-mail
Wednesday, 05 January 2011 21:55
Patients with autoimmune interstitial lung disease (ILD) — a frequently fatal chronic inflammatory autoimmune disease that causes scarring of the lungs — often have vitamin D deficiencies, and researchers from the University of Cincinnati believe this may affect the disease's pathogenesis.

In a study published in the Jan. 4 issue of Chest, researchers analyzed serum 25-hydroxyvitamin D levels in 118 patients from the center to determine whether vitamin D levels influenced disease progression.  Among study participants, 67 had connective tissue disease, whereas 51 patients had other causes of lung fibrosis.

“Since vitamin D has implications in other manifestations of autoimmune illnesses [including type 1 diabetes], we wanted to see if it had an effect on the lungs of this patient population,” Brent Kinder, MD, the director of the Interstitial Lung Disease Center at the university, said in a press release.

Kinder and colleagues found that patients who had connective tissue disease-related ILD — including those with rheumatoid arthritis, lupus and scleroderma — were more likely to have vitamin D deficiency (52% vs. 20%; P<.0001) and insufficiency (79% vs. 31%; P<.0001), compared with patients who had other forms of the disease.

Among patients with low vitamin-D levels and connective tissue disease-related ILD the researchers noted reduced lung function, including diminished forced vital capacity (P=0.015) and diffusing capacity for carbon monoxide (P=.004). These associations persisted even after adjusting for potential confounding factors (OR=11.8; P<.0001).

The researchers believe that vitamin D may play a role in worsening lung function in these patients and that supplements may be a safer, less expensive treatment for the illness than existing toxic therapies.

“One of the next steps is to see if supplementation will improve lung function for these patients,” Kinder said.

The researchers called for more clinical trials to “investigate the underlying molecular mechanisms of this observed association,” and additional “prospective controlled interventional studies […] to determine if vitamin D supplementation can ameliorate symptoms and improve outcomes.”

Source: Blazek, N. (2011), "Vitamin D deficiency may hasten autoimmune lung disease"; Source article can be viewed here.

 
More articles :

» Survival In Pulmonary Hypertension

Stephen C. Mathai, Laura K. Hummers, Hunter C. Champion, Fredrick M. Wigley, Ari Zaiman, Paul M. Hassoun, and Reda E. GirgisARTHRITIS & RHEUMATISMVol. 60, No. 2, February 2009, pp 569–577 DOI 10.1002/art.24267 © 2009, American College of...

» Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants

Systemic sclerosis is a multisystem, connective tissue disease of unknown aetiology characterized by vascular dysfunction, autoimmunity, and enhanced fibroblast activity resulting in fibrosis of the skin, heart, and lungs, and ultimately internal...

» Unite Against Scleroderma A Great Success

Our very first Scleroderma Awareness Walk, "Unite Against Scleroderma" was a great success. Sunday May 1st was a dream that became a reality, simply because family and friends of the Foundation also wanted the community of Trinidad and Tobago to be...

» Frequency of Sexual Dysfunction In Women With Rheumatic Diseases

Sexuality is part of human life and of quality of life, accounting for individual well-being. It relates not only to sexual intercourse itself, but also to a whole spectrum that ranges from self-image and self-valuing to relationship with the...

» The Keys To Healthy Living

The key to eating and living healthy is a balanced, nutritious diet. And to consume a balanced diet, you need to have foods from all the food groups, that is, fruits, vegetables, meats and poultry, whole grains, dairy products and oils/fats.You must...

» The Interplay Between Environmental and Genetic Factors in Autoimmune Disorders

Autoimmune disorders constitute a group of more than 80 different diseases characterized by immune attack of components of a person’s own body, mediated by and autoreactive T cells. Specifically, the common feature that defines autoimmune...