Systemic Sclerosis: A Bird’s Eye Review of Recent Literature PDF Print E-mail
Tuesday, 06 July 2010 10:49
Pathogenesis and new therapeutical targets
Transcription factor Fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis: In this study the authors investigated the potential pathogenetic role of Fos-related antigen-2 (Fra-2) for the peripheral microangiopathy in Fra-2 transgenic (tg) mice and in human systemic sclerosis (SSc) patients. Fra-2 is a transcription factor of the activator protein-1 (AP-1) family involved in the control of stress response including cell proliferation, apoptosis, inflammation, wound healing and tumorigenesis.

Login to download your own copy of the full review from the link provided below.

 
More articles :

» arGentis Issued Key Patent Related to Treating Fibrosing Diseases by Induction of Immune Tolerance

arGentis Pharmaceuticals, LLC today announced the issuance of United States patent 7,718,765, entitled “Methods for Treating Fibrosing Diseases by Induction of Immune Tolerance." The issued patent, based on the seminal research of Arnold E....

» Scleroderma Foundation Medical Advisory Board Offers Consensus On Gleevec

® (imatinib mesylate, Novartis) is approved in the United States for the treatment of certain forms leukemias and solid tumors. The recent discovery that Gleevec® inhibits important cellular enzymes that control fibrosis led to studies to evaluate...

» Development of a Five-Year Mortality Model in Systemic Sclerosis Patients

L. Beretta, A. Santaniello, F. Cappiello, N.V. Chawla, M.C. Vonk, P.E. Carreira, Y. Allanore, D.A. Popa-Diaconu, M. Cossu, F. Bertolotti, G. Ferraccioli, A. Mazzone, R. ScorzaReceived on November 17, 2009; accepted in revised form on October 5,...

» Rare Disease Research Teams Receive Over $17m In Funding

(CIHR) has formed 9 new research teams that will focus on rare diseases. Funding from the CIHR will total $15.4 million over five years, primarily through the Institute of Genetics and the Institute of Nutrition, Metabolism, and Diabetes, while...

» Methotrexate Effective In Juvenile Localized Scleroderma

is effective in when given with a short course of steroids, an Italian randomized study confirmed.Among children ages 6 to 17 receiving methotrexate, 67.4% completed the yearlong trial without flaring, compared with 29.2% of those given placebo...

» Geneticists Hunt for Scleroderma Triggers

In all its forms, gives Dartmouth geneticist Michael Whitfield, his graduate students, and his postdoctoral researchers a sense of urgency in their search for the triggers of the chronic condition. In a study that the Journal of Investigative...