|Systemic Sclerosis: A Bird’s Eye Review of Recent Literature|
|Tuesday, 06 July 2010 10:49|
Pathogenesis and new therapeutical targets
Transcription factor Fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis: In this study the authors investigated the potential pathogenetic role of Fos-related antigen-2 (Fra-2) for the peripheral microangiopathy in Fra-2 transgenic (tg) mice and in human systemic sclerosis (SSc) patients. Fra-2 is a transcription factor of the activator protein-1 (AP-1) family involved in the control of stress response including cell proliferation, apoptosis, inflammation, wound healing and tumorigenesis.
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