Systemic Sclerosis: A Bird’s Eye Review of Recent Literature PDF Print E-mail
Tuesday, 06 July 2010 10:49
Pathogenesis and new therapeutical targets
Transcription factor Fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis: In this study the authors investigated the potential pathogenetic role of Fos-related antigen-2 (Fra-2) for the peripheral microangiopathy in Fra-2 transgenic (tg) mice and in human systemic sclerosis (SSc) patients. Fra-2 is a transcription factor of the activator protein-1 (AP-1) family involved in the control of stress response including cell proliferation, apoptosis, inflammation, wound healing and tumorigenesis.

Login to download your own copy of the full review from the link provided below.

 
More articles :

» Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease

Tamiko R. Katsumoto, Shelia M. Violette, and Dean SheppardReceived 27 May 2011; Accepted 15 August 2011Interstitial lung disease (ILD) is a commonly encountered complication of systemic sclerosis (SSc) and accounts for a significant proportion of...

» More Research Needed to Understand Scleroderma

With an estimated 14 million cases worldwide, you would think more would be known about , a chronic, debilitating disease that can lead to the hardening and tightening of skin and connective tissue. But it seems that we don’t know enough: “We...

» Scleroderma Drug In Development

According to , has partnered with , the health care investment arm of Morgan Keegan and Co. Inc., to jump-start a capital campaign to raise $12 million to $15 million. ArGentis shelved the campaign last year when the economy soured.The money will...

» Special Surgery Scientists To Share Advances in Lupus and Related Conditions

Hospital for Special Surgery physicians who focus on lupus, scleroderma and related conditions are traveling from New York City to Atlanta this week to share their recent findings at the 74th Annual Scientific Meeting of the American College of...

» Scleroderma Herbal Treatments

is a connective tissue disease. It causes the skin and internal organs to become hard and tight. This hardening can make it difficult for the sufferer to walk or move and can cause organs to fail. According to the Scleroderma Foundation, in the...

» Kidney Involvement In Scleroderma

Kidney disease is one of the manifestations of vascular, or blood vessel involvement, in .Other manifestations of vascular disease in Scleroderma include Raynaud's phenomenon, telangiectasia (dilated blood vessels, most common on the face and...