Real-World Bosentan Therapy Successful in Pulmonary Arterial Hypertension: Presented at ATS PDF Print E-mail
Wednesday, 19 May 2010 19:52
Real-life experiences in treating patients with pulmonary arterial hypertension with bosentan appears to provide similar efficacy as seen in clinical trials -- despite patients being somewhat older and having more scleroderma, researchers said today here at the American Thoracic Society (ATS) 2010 International Conference.

"We also found that in our population of patients abnormal liver function tests were observed more often than in clinical trials," said Nathan Dwyer, MD, Pulmonary Medicine, Foothills Medical Center, Calgary, Alberta. He conducted his work at Royal Hobart Hospital, Hobart, Tasmania, Australia.

"Overall, we found that bosentan and other endothelin-receptor antagonists used to treat pulmonary arterial hypertension are effective in treating patients who may fall outside the tight criteria for patients in clinical trials," Dr. Dwyer said during his poster presentation.

He said that of the 152 patients treated in Tasmania, 23 patients developed abnormal liver function tests that required 20 of those patients to discontinue bosentan treatment. "You have to monitor these patients for liver function abnormalities very closely," he said.

Oedema also occurred frequently, occurring in 31 of his patients, but treatment with spironolactone was able to treat the oedema. Only 2 patients had to discontinue therapy due to oedema, he reported.

"The treated population differed from that in clinical trials by being older, having more Scleroderma, more comorbidities, and lower average walk distances," he said.

In the 6-minute walk test, subjects improved in their physical activity by about 60 metres from a baseline of about 300 metres. "We observed that this improvement was retained for at least 5 years," Dr. Dwyer said. The improvement was similar in those patients with idiopathic pulmonary arterial hypertension and in scleroderma pulmonary arterial hypertension.

"Bosentan was well tolerated and resulted in significant benefits over a 5-year period," he said. "These data represent what might be expected in a population including all morbidities."

The patients were followed from 2003 through 2008. The researchers achieved a 100% follow-up of these patients. Their mean age was 63 years, and 121 of the participants were women. All of the patients were in New York Heart Association class 3 or 4.

Funding for this study was provided by Actelion, CSL, and Bayer.

Source: Doctor's Guide
 
More articles :

» New Stem Cell Therapy To Help With Stubborn Wounds

The skin is the largest organ in the body with amazing healing powers, but what if your wounds didn't heal?That's the case for 6 million Americans suffering from chronic wounds that can take months, even years, to heal. Millions have no other choice...

» No Exercise Benefit with Bosentan in Systemic Sclerosis

Treatment with the endothelin receptor antagonist bosentan () failed to improve exercise capacity in patients with systemic sclerosis, a randomized trial found. After one year of treatment, there was a nonsignificant mean change in the six-minute...

» 5 Cold And Flu Prevention Tips

With some 20,000 cases of flu having been reported in New York state and many more throughout the rest of the United States, many have declared this year's cold and flu season to be of epidemic proportions. According to the , the 2012-13 flu season...

» The Inspirational Story of Haley Pilkington

Haley Pilkington is a remarkable singer for reasons far beyond her 14 years and the dynamic voice that so effortlessly uplifts anyone who hears her sing. Haley is a student of Deborah “Zuke” Smith, a Brett Manning Associate whose students...

» Unite Against Scleroderma

{gallery}unite{/gallery}

» Skin Autofluorescence Is Not Increased in Patients with Systemic Sclerosis

M. E. Hettema, H. Bootsma, R. Graaff, R. de Vries, C. G. M. Kallenberg, and A. J. SmitReceived 24 May 2011; Accepted 8 August 2011Vascular involvement is a key factor in major manifestations of systemic sclerosis (SSc), such as Raynaud’s...